Drug Target Set Enrichment Analysis
Calculate between variance in network
Function to calculate the p0 vector used in Random Walk with Restart (...
Calculate within variance
Cronbach's alpha
The Drug target set enrichment analysis (DTSEA)
Main function of drug target set enrichment analysis (DTSEA)
Get extra data
Kendall's coefficient of concordance W
Function to implement Random Walk with Restart (RwR) algorithm on the ...
A measure of network separation
It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi: 10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi: 10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi: 10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi: 10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi: 10.1093/nar/gkaa970> for the details of KEGG database.)