A Concentration-Response Modeling Utility
AC GNLS Objective Function
Activity Concentration y
BMD Bounds
BMD Objective Function
Empirically locate top and top concentration
Constant Model
Concentration Response Core
Concentration Response Plot
Concentration Response Plot - ggplot2
Exponential 2 Model
Exponential 3 Model
Exponential 4 Model
Exponential 5 Model
Constant Model Fit
Exponential 2 Model Fit
Exponential 3 Model Fit
Exponential 4 Model Fit
Exponential 5 Model Fit
Gain-Loss Model Fit
Hill Model Fit
Polynomial 1 (Linear) Model Fit
Polynomial 2 (Quadratic) Model Fit
Power Model Fit
Calculate Area Under the Curve (AUC)
Gain-Loss Model
GNLS Derivative Objective Function
Hill Model
Continuous Hitcalls
Continuous Hitcalls Inner
Hit Logic (Discrete)
Hit Logic Inner (Discrete)
Log Gain-Loss Model
Log Hill Model
Nest Select
Plot All Curves Fit with tcplfit2_core - ggplot2
Polynomial 1 Model
Polynomial 2 Model
Polynomial 2 Model (BMDS)
Calculate Area Under the Curve After Hit-calling
Power Model
Concentration-response curve fitting
Hitcalling Function
Concentration Response Objective Function
Top Likelihood
The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.
Useful links