Mehta dataset

Mehta Trial

For a 22-centre trial the number of responses and the total number of patients is reported for the control group and the group receiving a new drug. data

data("Mehta")

Format

A data frame with 44 observations on the following 4 variables.

• Response: Number of responses.
• Total: Total number of observations.
• Drug: A factor indicating treatment with levels New and Control.
• Site: A factor indicating the site/centre.

Source

M. Aitkin. Meta-analysis by random effect modelling in generalized linear models. Statistics in Medicine, 18 , 2343--2351, 1999.

References

C.R. Mehta, N.R. Patel and P. Senchaudhuri. Importance sampling for estimating exact probabilities in permutational inference. Journal of the American Statistical Association, 83, 999--1005, 1988.

Examples

data("Mehta", package = "flexmix")
mehtaMix <- initFlexmix(cbind(Response, Total-Response) ~ 1|Site, 
                        data = Mehta, nrep = 5, k = 3,
                        model = FLXMRglmfix(family = "binomial",
                          fixed = ~ Drug), 
                        control = list(minprior = 0.04))