PBG dataset

Effect of Phenylbiguanide on Blood Pressure

The PBG data frame has 60 rows and 5 columns.

Format

This data frame contains the following columns:

• deltaBP: a numeric vector

• dose: a numeric vector

• Run: an ordered factor with levels T5 < T4 < T3 < T2 < T1 < P5 < P3 < P2 < P4 < P1

• Treatment: a factor with levels MDL 72222

    `Placebo`
  

• Rabbit: an ordered factor with levels 5 < 3 < 2 < 4 < 1

Details

Data on an experiment to examine the effect of a antagonist MDL 72222 on the change in blood pressure experienced with increasing dosage of phenylbiguanide are described in Ludbrook (1994) and analyzed in Venables and Ripley (2002, section 10.3). Each of five rabbits was exposed to increasing doses of phenylbiguanide after having either a placebo or the HD5-antagonist MDL 72222 administered.

Source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.21)

Venables, W. N. and Ripley, B. D. (2002) Modern Applied Statistics with S (4th ed), Springer, New York.

Ludbrook, J. (1994), Repeated measurements and multiple comparisons in cardiovascular research, Cardiovascular Research, 28 , 303-311.