Adaptive Subgroup Selection in Group Sequential Trials
Is a scalar quantity is a specified range?
Three stage group sequential adaptive design with subgroup selection
A class to encapsulate the adaptive clinical trial design of Lai, Lavo...
A fixed sample design to compare against the adaptive clinical trial d...
A fixed sample RCT design to compare against the adaptive clinical tri...
Return a vector of column names for statistics for a given stage
Compute the mean and sd of a discrete Rankin distribution
Compute the three modified Haybittle-Peto boundaries
Compute the three modified Haybittle-Peto boundaries and effect size
Conform designParameters so that weights are turned in to probabilitie...
The DEFUSE3 design
A data generation function using a discrete distribution for Rankin sc...
A data generation function along the lines of what was used in the Lai...
Compute the sample size for any group at a stage assuming a nested str...
Compute the efficacy boundary (modified Haybittle-Peto) for the first ...
Compute the futility boundary (modified Haybittle-Peto) for the first ...
Compute the efficacy boundary (modified Haybittle-Peto) for the final ...
Compute the standardized Wilcoxon test statistic for two samples
Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, <doi:10.1016/j.cct.2014.09.001>). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.