A_sampling function

Regulation Strength Sampling Function

Function 'A_sampling' estimates a regulation strength for each sampled binding event in C, according to a posterior Gaussian distribution.

A_sampling(Y, C, A_old, X, base_line, C_prior, sigma_noise, sigma_A,
  sigma_baseline, sigma_X)

Arguments

• Y: gene expression data matrix
• C: sampled TF-gene binding network
• A_old: regulatory strength sampled from the previous round, used as a prior in current function
• X: sampled transcription factor activity matrix
• base_line: sampled gene expression baseline activity
• C_prior: prior TF-gene binding network
• sigma_noise: variance of gene expression fitting residuals
• sigma_A: variance of regulatory strength
• sigma_baseline: variance of gene expression baseline activity
• sigma_X: variance of transcription factor activity