X_sampling function

Transcription Factor Activity Sampling Function

Function 'X_sampling' estimates the hidden activities of each transcription factor, according to a posterior Gaussian random process.

X_sampling(Y, C, A, X_old, base_line, C_prior, sigma_noise, sigma_A,
  sigma_baseline, sigma_X)

Arguments

• Y: gene expression data matrix
• C: sampled TF-gene binding network
• A: sampled regulatory strength matrix
• X_old: sampled transcription factor activity matrix from the previous round
• base_line: sampled gene expression baseline activity
• C_prior: prior TF-gene binding network
• sigma_noise: variance of gene expression fitting residuals
• sigma_A: variance of regulatory strength
• sigma_baseline: variance of gene expression baseline activity
• sigma_X: variance of transcription factor activity