Clustering of Genomic Regions Analysis Method
CREAM is the main function for CORE identification
ElementRecog is a function to identify COREs
PeakMinFilt is a function to filter the lowest Order of COREs which di...
WindowSizeRecog is a function to specify window size for each order of...
WindowVec is a function to specify window size for each order of COREs
Provides a new method for identification of clusters of genomic regions within chromosomes. Primarily, it is used for calling clusters of cis-regulatory elements (COREs). 'CREAM' uses genome-wide maps of genomic regions in the tissue or cell type of interest, such as those generated from chromatin-based assays including DNaseI, ATAC or ChIP-Seq. 'CREAM' considers proximity of the elements within chromosomes of a given sample to identify COREs in the following steps: 1) It identifies window size or the maximum allowed distance between the elements within each CORE, 2) It identifies number of elements which should be clustered as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which does not pass the threshold considered in the approach.