Comprehensive Batch Effect Diagnostics and Harmonization
Age Trend Estimates Generation
Export Brain ROI Age Trends
Lifespan Age Trends
Generate Age Trend Summary Table
Generate Age Trend Plot
ComBatFamily Harmonization
Generate Diagnostic Plots for Batch Effect Analysis
Generate Diagnostic Tables for Batch Effect Analysis
Batch Effect Interactive Visualization
ComBat Family Harmonization
CovBat Family Harmonization
Generate Customized Predicted Quantiles List
Generate Predicted Quantiles for Age Trends
Data Preparation
Export Batch Effect Diagnosis Results
Biweight Midvariance Calculation
EB Assumption Check
ComBatFamily Model Formula Generations
Compute Quantile Functions for a Predictor in a GAMLSS Model
Interaction Term Generation
Model Generations
Apply Harmonization to New Data
Post Harmonization Residual Generation
Batch Effect Diagnostic Visualization Preparation
Provides a comprehensive framework for batch effect diagnostics, harmonization, and post-harmonization downstream analysis. Features include interactive visualization tools, robust statistical tests, and a range of harmonization techniques. Additionally, 'ComBatFamQC' enables the creation of life-span age trend plots with estimated age-adjusted centiles and facilitates the generation of covariate-corrected residuals for analytical purposes. Methods for harmonization are based on approaches described in Johnson et al., (2007) <doi:10.1093/biostatistics/kxj037>, Beer et al., (2020) <doi:10.1016/j.neuroimage.2020.117129>, Pomponio et al., (2020) <doi:10.1016/j.neuroimage.2019.116450>, and Chen et al., (2021) <doi:10.1002/hbm.25688>.
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