s: a vector of variables containing the six free parameters in the S matrix
pix: a vector giving the stationary probabilities for the four nucleotides A, C, G and T
Details
This function calculates the matrix S, which we used to calculate the rate matrix R.
Returns
A 4 x 4 symmetric matrix
References
Faisal Ababneh, Lars S Jermiin, Chunsheng Ma, John Robinson (2006). Matched-pairs tests of homogeneity with applications to homologous nucleotide sequences. Bioinformatics, 22(10), 1225-1231.