Predict.Treat.ContCont function

Compute the predicted treatment effect on the true endpoint of a patient based on his or her observed pretreatment predictor value in the continuous-continuous setting

This function computes the predicted $\Delta T_j$ of a patient based on the pretreatment value $S_j$ of a patient in the continuous-continuous setting.

Predict.Treat.ContCont(x, S, Beta, SS, mu_S)

Arguments

• x: An object of class PCA.ContCont. See PCA.ContCont.
• S: The observed pretreatment value $S_j$ for a patient.
• Beta: The estimated treatment effect on the true endpoint (in the validation sample).
• SS: The estimated variance of the pretreatment predictor endpoint.
• mu_S: The estimated mean of the pretreatment predictor (in the validation sample).

Returns

An object of class PCA.Predict.Treat.ContCont with components, - Pred_T: The predicted $\Delta T_j$.

• Var_Delta.T: The variance $\sigma_{\Delta_{T}}.$

• T0T1: The correlation between the counterfactuals $T_{0}$, $T_{1}$.

• PCA: The vector of $\rho_{\psi}$ values.

• Var_Delta.T_S: The variance $\sigma_{\Delta_{T}}$|$S_j$.

References

Alonso, A., Van der Elst, W., & Molenberghs, G. (submitted). Validating predictors of therapeutic success: a causal inference approach.

Author(s)

Wim Van der Elst, Ariel Alonso, & Geert Molenberghs

See Also

PCA.ContCont

Examples

# Generate the vector of PCA.ContCont values when rho_T0S=.3, rho_T1S=.9, 
# sigma_T0T0=2, sigma_T1T1=2,sigma_SS=2, and the grid of values {-1, -.99, 
# ..., 1} is considered for the correlations between T0 and T1:
PCA <- PCA.ContCont(T0S=.3, T1S=.9, T0T0=2, T1T1=2, SS=2, 
T0T1=seq(-1, 1, by=.01))

# Obtain the predicted value T for a patient who scores S = 10, using beta=5,
# SS=2, mu_S=4
Predict <- Predict.Treat.ContCont(x=PCA, S=10, Beta=5, SS=2, mu_S=4)

# examine the results
summary(Predict)

# plot Delta_T_j given S_T, for the mean value of the valid rho_T0T1  
plot(Predict, Mean.T0T1=TRUE, Median.T0T1=FALSE)