Genotype-Specific Survival Estimation
Permutation Test
EM-PAVA function
Genotype-Specific Survival Estimation
Probability Calculation of Relative's Mutation Status
Sieve_NPMLE_Bootstrap function
Sieve_NPMLE_Switch function
Kolmogorov-Smirnov Test Statistic
We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.