Group Sequential Design for Historical Control Trial with Survival Outcome
Calculate Calendar Times for Interim Analysis Looks
HCT design with interim monitoring for efficacy only
Monitoring the trial at interim looks for a trial with efficacy monito...
HCT design with interim monitoring for futiity only
Monitoring the trial at interim looks for a trial with futility monito...
HCT design with interim monitoring for both efficacy and futility
Monitoring the trial at interim looks for a trial with efficacy and fu...
Log rank test for non-inferiority trial
Sample size in terms of number of subjects in the experimental group
It provides functions to design historical controlled trials with survival outcome by group sequential method. The options for interim look boundaries are efficacy only, efficacy & futility or futility only. It also provides the function to monitor the trial for any unplanned look. The package is based on Jianrong Wu, Xiaoping Xiong (2016) <doi:10.1002/pst.1756> and Jianrong Wu, Yimei Li (2020) <doi:10.1080/10543406.2019.1684305>.