Calculate the chi-squared statistic from observed and expected counts using the Litchfield and Wilcoxon (1949) approach.
LWchi2(obsn, expn, totn)
Arguments
obsn: A numeric vector of observed counts.
expn: A numeric vector of expected counts, the same length as obsn.
totn: A numeric vector of total counts possible, the same length as obsn.
Returns
A list of length two. The first element is a numeric vector of length three: chistat, chi-squared statistic; df, degrees of freedom; and pval, P value. The second element is a numeric vector the same length as obsn, containing total contributions to the chi-squared. To get the individual contributions to the chi-squared as reported in Litchfield and Wilcoxon (1949), divide by totn.
Details
The denominator of Litchfield and Wilcoxon's (1949) chi-squared estimate is the minimum of the expn and (totn - expn) following their Nomograph No. 1. This ensures that the same chi-squared value is calculated regardless of which proportion is reported (e.g., affected vs. not affected).
Examples
LWchi2(c(10,8,3), c(7,7,7), c(12,12,12))
References
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].