Microbiome Regression-Based Kernel Association Tests
Small-sample SKAT for correlated (continuous) data ('c' stands for 'co...
D2K
The Microbiome Regression-based Kernel Association Test Based on the G...
Inner Function for CSKAT, Correlated Sequence Kernel Association Test
Kernel RV Coefficient Test; Inner Function
Kernel RV Coefficient Test (KRV)
MiRKAT-iQ
Robust MiRKAT (quantile regression)
Robust MiRKAT (robust regression)
Microbiome Regression-based Kernel Association Test
Microbiome Regression-Based Kernel Association Test for binary outcome...
Microbiome Regression-based Analysis Test for a continuous outcome var...
Microiome Regression-based Kernel Association Test for Survival
Multivariate Microbiome Regression-based Kernel Association Test
Test for overall association between microbiome composition data and phenotypes via phylogenetic kernels. The phenotype can be univariate continuous or binary (Zhao et al. (2015) <doi:10.1016/j.ajhg.2015.04.003>), survival outcomes (Plantinga et al. (2017) <doi:10.1186/s40168-017-0239-9>), multivariate (Zhan et al. (2017) <doi:10.1002/gepi.22030>) and structured phenotypes (Zhan et al. (2017) <doi:10.1111/biom.12684>). The package can also use robust regression (unpublished work) and integrated quantile regression (Wang et al. (2021) <doi:10.1093/bioinformatics/btab668>). In each case, the microbiome community effect is modeled nonparametrically through a kernel function, which can incorporate phylogenetic tree information.