Simulation and Analysis of Platform Trials with Non-Concurrent Controls
Wrapper function for simulations performing inference on given treatme...
Simulate binary data from a platform trial with a shared control arm a...
Simulate continuous data from a platform trial with a shared control a...
Frequentist logistic regression model analysis for binary data adjusti...
Frequentist logistic regression model analysis for binary data adjusti...
Frequentist linear regression model analysis for continuous data adjus...
Frequentist linear regression model analysis for continuous data adjus...
Generalized additive model analysis for continuous data
Sample size matrix for a platform trial with a given number of treatme...
Generation of an inverted-u trend
Generation of a linear trend that starts in a given period
Analysis for binary data using the MAP Prior approach
Analysis for continuous data using the MAP Prior approach
Mixed regression model analysis for continuous data adjusting for cale...
Mixed regression model analysis for continuous data adjusting for peri...
Mixed regression model analysis for continuous data adjusting for cale...
Mixed regression model analysis for continuous data adjusting for peri...
Model-based analysis for continuous data using discontinuous piecewise...
Model-based analysis for continuous data using discontinuous piecewise...
Function for visualizing the simulated trial
Pooled analysis for binary data
Pooled analysis for continuous data
Generation of a seasonal trend
Separate analysis for binary data adjusted for periods
Separate analysis for continuous data adjusted for periods
Separate analysis for binary data
Separate analysis for continuous data
Wrapper function performing simulation studies for a given set of scen...
Wrapper function performing simulation studies for a given set of scen...
Spline regression analysis for continuous data with knots placed accor...
Spline regression analysis for continuous data with knots placed accor...
Generation of stepwise trend with equal jumps between periods
Time machine analysis for binary data
Time machine analysis for continuous data
Design and analysis of flexible platform trials with non-concurrent controls. Functions for data generation, analysis, visualization and running simulation studies are provided. The implemented analysis methods are described in: Bofill Roig et al. (2022) <doi:10.1186/s12874-022-01683-w>, Saville et al. (2022) <doi:10.1177/17407745221112013> and Schmidli et al. (2014) <doi:10.1111/biom.12242>.