NMsim0.1.5 package

Create function that adds text elements to vector

Add simulation records to dosing records

Add residual variability based on parameter estimates

Generate system command to call Nonmem directly

Test if file modification times indicate that Nonmem models should be ...

Drop spaces and odd characters. Use to ensure generated file names are...

Expand a set of covariate values into a data.set with reference value

Apply function and return a data.table

Create data set where each covariate is univariately varied

Filter control streams to only those updated since last run

Generate a .phi file for further simulation with Nonmem

Default location of input archive file

Easily and flexibly generate dosing records

Create text lines for OMEGA and SIGMA Nonmem sections

Execute Nonmem and archive input data with model files

Execute Nonmem inside a dedicated directory

Generate PNM file for sge clusters

Read simulation results based on NMsim's track of model runs

Read simulation results from rds objects and/or NMsimModTab objects

Read simulation results from an rds or a NMsimModTab object

Read simulation results from data.frames or fst files

read one sim element. This will be run in lapply in NMreadSim.

Replace initial values in Nonmem control stream

Internal function to run Nonmem on linux

Add seed string to simulation model data.table

Simulation method that uses the provided control stream as is

Transform an estimated Nonmem model into a simulation control stream

Use emperical Bayes estimates to simulate re-using ETAs

NMsim_known is an old name for NMsim_EBE()

Simulate with parameter variability using the NONMEM NWPRI subroutine

Typical subject simiulation method

Simulate with parameter values sampled from a covariance step

Simulate from an estimated Nonmem model

Check a simulation control streams for things that can cause trouble i...

Remove NMsimModTab class and discard NMsimModTab meta data

Remove NMsimRes class and discard NMsimRes meta data

Summarize and test NMsim configuration

Create new Nonmem control stream with updated initial parameter values

Add degrees of freedom by OMEGA/SIGMA block

Create function that modifies text elements in a vector

pad zeros on integers

Print OMEGA and SIGMA matrices for NONMEM sections in block format. No...

Parameter data from csv

Sample model parameters using the simpar package

Check that a variable is a single character string meeting specified r...

Generate a population based on a Nonmem model

Summarize simulated exposures relative to reference subject

Conveniently writeLines to file