AUC function

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format

Calculate Area Under the Curve(AUC) and the first Moment Curve(AUMC) in two ways; 'linear trapezoidal method' or 'linear-up and log-down' method. Return a table of cumulative values.

AUC(x, y, down = "Linear")

Arguments

• x: vector values of independent variable, usually time
• y: vector values of dependent variable, usually concentration
• down: either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC

Details

down="Linear" means linear trapezoidal rule with linear interpolation. down="Log" means linear-up and log-down method.

Returns

Table with two columns, AUC and AUMC; the first column values are cumulative AUCs and the second column values cumulative AUMCs.

References

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. pp687-689. 2011.

Author(s)

Kyun-Seop Bae k@acr.kr

See Also

LinAUC, LogAUC

Examples

AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"])
AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], down="Log")