IntAUC function

Calculate interval AUC

It calculates interval AUC

IntAUC(x, y, t1, t2, Res, down = "Linear")

Arguments

• x: vector values of independent variable, usually time
• y: vector values of dependent variable, usually concentration
• t1: start time for AUC
• t2: end time for AUC
• Res: result from sNCA function
• down: either of "Linear" or "Log" to indicate the way to calculate AUC

Details

This calculates an interval (partial) AUC (from t1 to t2) with the given series of x and y. If t1 and/or t2 cannot be found within x vector, it interpolates according to the down option.

Returns

return interval AUC value (scalar)

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Author(s)

Kyun-Seop Bae k@acr.kr

See Also

AUC, Interpol

Examples

Res = sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], 
           dose=320, concUnit="mg/L")
IntAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], t1=0.5, t2=11, Res)