LogAUC function

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method

It calculates AUC and AUMC using the linear-up log-down method

LogAUC(x, y)

Arguments

• x: vector values of the independent variable, usually time
• y: vector values of the dependent variable, usually concentration

Details

This function returns AUC and AUMC by the linear-up log-down method.

Returns

• AUC: area under the curve

• AUMC: area under the first moment curve

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Author(s)

Kyun-Seop Bae k@acr.kr

See Also

LinAUC,AUC

Examples

LogAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"])
# Compare the last line with the above
AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], down="Log")