gAUC function

General Area Under the Curve

General AUC function for Emax, TEmax and AUCs

gAUC(x, y, Ymax = "Emax", XofYmax = "TEmax", AUCname = "AUEClast", iAUC = "", 
     Outer = "NEAREST")

Arguments

• x: usually time
• y: usually concentration or effect. This can be negative/
• Ymax: usually Cmax or Emax
• XofYmax: usually Tmax or TEmax
• AUCname: usually AUClast or AUEClast
• iAUC: a data.frame to calculate interval AUCs
• Outer: indicates how to do the out of x range point

Details

This is a general purpose AUC function. It calculates only Cmax(Emax), Tmax(TEmax) and AUCs(AUECs). This can be used for effect(pharmacodynamic) data which has negative values. For concentration data, use IntAUC.

Returns

Column names can vary according to the options. - Emax: maximum y value

• TEmax: x value at the maximum y value

• AUEClast: Area under the y versus x curve

• iAUCs: Columns from iAUC input

Author(s)

Kyun-Seop Bae k@acr.kr

Examples

# For one subject
x = Theoph[Theoph$Subject=="1", "Time"]
y = Theoph[Theoph$Subject=="1", "conc"]
gAUC(x, y)

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
gAUC(x, y, iAUC=iAUC)