sNCA function

Simplest NCA

Simplest NCA

This is the work-horse function for NCA.

sNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
     concUnit = "ug/L", iAUC = "", down = "Linear", R2ADJ = 0.7, MW = 0, SS = FALSE, 
     Keystring="", excludeDelta = 1)

Arguments

  • x: usually time
  • y: usually concentration
  • dose: given amount, not amount per body weight
  • adm: one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode
  • dur: duration of infusion
  • doseUnit: unit of dose
  • timeUnit: unit of time
  • concUnit: unit of concentration
  • iAUC: interval AUCs to calculate
  • down: either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC
  • R2ADJ: Minimum adjusted R-square value to determine terminal slope automatically
  • MW: molecular weight of the drug
  • SS: if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
  • Keystring: a text string to be shown at the plot in case of manual selection of terminal slope
  • excludeDelta: Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Details

This replaced previous IndiNCA. Author recommends to use excludeDelta option with about 0.3.

Returns

  • CMAX: maximum concentration, Cmax

  • CMAXD: dose normalized Cmax, CMAX / Dose, Cmax / Dose

  • TMAX: time of maximum concentration, Tmax

  • TLAG: time to observe the first non-zero concentration, for extravascular administration only

  • CLST: last positive concentration observed, Clast

  • CLSTP: last positive concentration predicted, Clast_pred

  • TLST: time of last positive concentration, Tlast

  • LAMZHL: half-life by lambda z, ln(2)/LAMZ

  • LAMZ: lambda_z negative of the best-fit terminal slope

  • LAMZLL: earliest time for LAMZ

  • LAMZUL: last time for LAMZ

  • LAMZNPT: number of points for LAMZ

  • CORRXY: correlation of log(concentration) and time

  • R2: R-squared

  • R2ADJ: R-squared adjusted

  • C0: back extrapolated concentration at time 0, for intravascular bolus administration only

  • AUCLST: AUC from 0 to TLST

  • AUCALL: AUC using all the given points, including trailing zero concentrations

  • AUCIFO: AUC infinity observed

  • AUCIFOD: AUCIFO / Dose

  • AUCIFP: AUC infinity predicted using CLSTP instead of CLST

  • AUCIFPD: AUCIFP / Dose

  • AUCPEO: AUC % extrapolation observed

  • AUCPEP: AUC % extrapolated for AUCIFP

  • AUCPBEO: AUC % back extrapolation observed, for bolus IV administration only

  • AUCPBEP: AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only

  • AUMCLST: AUMC to the TLST

  • AUMCIFO: AUMC infinity observed using CLST

  • AUMCIFP: AUMC infinity determined by CLSTP

  • AUMCPEO: AUMC % extrapolated observed

  • AUMCPEP: AUMC % extrapolated predicted

  • MRTIVLST: mean residence time (MRT) to TLST, for intravascular administration

  • MRTIVIFO: mean residence time (MRT) infinity using CLST, for intravascular administration

  • MRTIVIFP: mean residence time (MRT) infinity using CLSTP, for intravascular administration

  • MRTEVLST: mean residence time (MRT) to TLST, for extravascular administration

  • MRTEVIFO: mean residence time (MRT) infinity using CLST, for extravascular administration

  • MRTEVIFP: mean residence time (MRT) infinity using CLSTP, for extravascular administration

  • VZO: volume of distribution determined by LAMZ and AUCIFO, for intravascular administration

  • VZP: volume of distribution determined by LAMZ and AUCIFP, for intravascular administration

  • VZFO: VZO for extravascular administration, VZO/F, F is bioavailability

  • VZFP: VZP for extravascular administration, VZP/F, F is bioavailability

  • CLO: clearance using AUCIFO, for intravascular administration

  • CLP: clearance using AUCIFP, for intravascular administration

  • CLFO: CLO for extravascular administration, CLO/F, F is bioavailability

  • CLFP: CLP for extravascular administration, CLP/F, F is bioavailability

  • VSSO: volume of distribution at steady state using CLST, for intravascular administration only

  • VSSP: volume of distribution at steady state using CLSTP, for intravascular administration only

References

Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

Author(s)

Kyun-Seop Bae k@acr.kr

See Also

help, tblNCA

Examples

# For one subject
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]

sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
sNCA(x, y, dose=320, concUnit="mg/L")

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)

MW = 180.164 # Molecular weight of theophylline

sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h")
sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h", MW=MW)
sNCA(x, y, dose=320/MW, doseUnit="mmol", concUnit="mg/L", timeUnit="h", MW=MW)
sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)

sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
sNCA(x, y/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
sNCA(x, y/MW, dose=as.numeric(NA), doseUnit="mmol", concUnit="mmol/L", timeUnit="h", 
     MW=MW)

sNCA(x, y, dose=320, concUnit="mg/L", timeUnit="hr")
sNCA(x*60, y, dose=320, concUnit="mg/L", timeUnit="min")
NonCompart packageRead PDF manual