tblNCA function

Table output NCA

Do multiple NCA and returns a result table. See sNCA for more detail i.e. iAUC

tblNCA(concData, key = "Subject", colTime = "Time", colConc = "conc", dose = 0, 
       adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
       concUnit = "ug/L", down = "Linear", R2ADJ = 0, MW = 0, SS = FALSE, 
       iAUC = "", excludeDelta = 1)

Arguments

• concData: concentration data table
• key: column names of concData to be shown in the output table
• colTime: column name for time
• colConc: column name for concentration
• dose: administered dose
• adm: one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode
• dur: duration of infusion
• doseUnit: unit of dose
• timeUnit: unit of time
• concUnit: unit of concentration
• down: method to calculate AUC, "Linear" or "Log"
• R2ADJ: Lowest threshold of adjusted R-square value to do manual slope determination
• MW: molecular weight of drug
• SS: if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
• iAUC: data.frame for interval AUC
• excludeDelta: Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Details

Tabular output of NCA with many subjects. Author recommends to use excludeDelta option with about 0.3.

Returns

Basically same with sNCA

Author(s)

Kyun-Seop Bae k@acr.kr

See Also

help, sNCA

Examples

tblNCA(Theoph, key="Subject", dose=320, concUnit="mg/L")
tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25, 
       adm="Infusion", dur=0.5, concUnit="mg/L")