Simulating and Conducting Phase 123 Trials
Gives operating characteristics of phase 123 and conventional design.
Simulates repitions of an Adaptive Eff-Tox Trial.
Simulates replications of the phase123 and phase 12-3 trials.
Performs one replication of phase 3 for the phase 123 design, given ph...
Determines the optimal dose to assign the next patient cohort.
Obtains estimated posterior probabilities of the four outcomes of (YE,...
Returns posterior distribution for key mixture model parameters
Randomizes Eff-Tox dose proportional to posterior desireability scores...
Gives the Optimal Dose for enrolling next patient cohort.
Gives the Optimal Dose for enrolling next patient cohort. Used in the ...
Gives true mean survival times for the control therapy.
Gives true mean survival times for doses considered of the experimenta...
Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.