'Trial Sequential Analysis' for Error Control and Inference in Sequential Meta-Analyses
Boundaries for group sequential designs
Inference calculations for sequential meta-analysis
Fixed-effect or random-effects meta-analysis
Minimum number of trials needed for a specific level of power
Plot of boundaries for group sequential designs
Forestplot for metaanalysis object.
Plot RTSA object. Returns the R version of the original TSA plot.
Calculate required sample and trials size.
R version of Trial Sequential Analysis. Used for designing and analysi...
Frequentist sequential meta-analysis based on 'Trial Sequential Analysis' (TSA) in programmed in Java by the Copenhagen Trial Unit (CTU). The primary function is the calculation of group sequential designs for meta-analysis to be used for planning and analysis of both prospective and retrospective sequential meta-analyses to preserve type-I-error control under sequential testing. 'RTSA' includes tools for sample size and trial size calculation for meta-analysis and core meta-analyses methods such as fixed-effect and random-effects models and forest plots. TSA is described in Wetterslev et. al (2008) <doi:10.1016/j.jclinepi.2007.03.013>. The methods for deriving the group sequential designs are based on Jennison and Turnbull (1999, ISBN:9780849303166).