Design and Analyze Studies using the Sequential Parallel Comparison Design
Creates a test data set for the example
Example of helper function for determining placebo nonresponse
Runs a constrained longitudinal data analysis model for use with `SPCD...
Runs a random slopes model for use with SPCDcontinuous
Analyze a Sequential Parallel Comparison Design(SPCD), study with a bi...
Analyze continuous data for the Sequential Parallel Comparison Design(...
Calculate the power, sample size for a Sequential Parallel Comparison ...
Programs to find the sample size or power of studies using the Sequential Parallel Comparison Design (SPCD) and programs to analyze such studies. This is a clinical trial design where patients initially on placebo who did not respond are re-randomized between placebo and active drug in a second phase and the results of the two phases are pooled. The method of analyzing binary data with this design is described in Fava,Evins, Dorer and Schoenfeld(2003) <doi:10.1159/000069738>, and the method of analyzing continuous data is described in Chen, Yang, Hung and Wang (2011) <doi:10.1016/j.cct.2011.04.006>.