SQUIRE1.0.1 package

Provides systematic geometry-adaptive parameter optimization with statistical validation for experimental biological data. Combines ANOVA-based validation with systematic constraint configuration testing (log-scale, positive domain, Euclidean) through T,P,E testing. Only proceeds with parameter optimization when statistically significant biological effects are detected, preventing over-fitting to noise. Uses 'GALAHAD' trust region methods with constraint projection from Conn et al. (2000) <doi:10.1137/S1052623497325107>, ANOVA-based validation following Fisher (1925) <doi:10.1007/978-1-4612-4380-9_6>, and effect size calculations per Cohen (1988, ISBN:0805802835). Designed for structured experimental data including kinetic curves, dose-response studies, and treatment comparisons where appropriate parameter constraints and statistical justification are important for meaningful biological interpretation. Developed at the Minnesota Center for Prion Research and Outreach at the University of Minnesota.

Useful links

• https://github.com/RFeissIV/SQUIRE/issues
• https://github.com/RFeissIV/SQUIRE