SpaCCI1.0.4 package

Spatially Aware Cell-Cell Interaction Analysis

Find_regional_IDs

Find the spatial neighborhood Spot IDs

GetShuffledCT

Perform a Deranged Shuffle of Cell Types

Global_Permutations

Perform Global Permutations

Local_Regional_Permutations

Perform Local and Regional Permutations

LR_database

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

plot_localized_Seurat

Plot Localized Hotspot Pattern on Seurat Object

plot_localized

Plot Localized Hotspot Pattern

plot_SpaCCI_chordDiagram

Plot SpaCCI Results on Chord Diagram

plot_SpaCCI_heatmap

Plot SpaCCI Results on the heatmap Visualize inferred significant cell...

plot_SpaCCI_local_Strength

Plot SpaCCI Localized Interaction Strength Results

plot_SpaCCI_local

Plot SpaCCI Localized Interaction Results

plot_Strength_localized

Plot Localized Hotspot Strength Pattern

plot_Strength_Seurat

Plot Localized Hotspot Strength Pattern on Seurat Object

possible_L_R_pairs_cellchat

CellChat Database: Identify Possible Ligand-Receptor Pairs for Cell-Ce...

possible_L_R_pairs_Cellinker

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

possible_L_R_pairs_cellphoneDB

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

possible_L_R_pairs_connectome

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

possible_L_R_pairs_ICELLNET

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

random_region

Select Closest Spatial IDs to a Center Point: this is used for permuta...

run_SpaCCI

Run SpaCCI Analysis

scPalette

Generate a Color Palette

self_identified_LR

Identify Possible Ligand-Receptor Pairs for Cell-Cell Communication

SpaCCI_global

Infer Cell-Cell Interactions on a Global Scale

SpaCCI_local

Infer Cell-Cell Interactions on a Local Scale

SpaCCI_region

Infer Cell-Cell Interactions in a Specified Region

Provides tools for analyzing spatial cell-cell interactions based on ligand-receptor pairs, including functions for local, regional, and global analysis using spatial transcriptomics data. Integrates with databases like 'CellChat' <http://www.cellchat.org/>, 'CellPhoneDB' <https://www.cellphonedb.org/>, 'Cellinker' <https://www.rna-society.org/cellinker/index.html>, 'ICELLNET' <https://github.com/soumelis-lab/ICELLNET>, and 'ConnectomeDB' <https://humanconnectome.org/software/connectomedb/> to identify ligand-receptor pairs, visualize interactions through heatmaps, chord diagrams, and infer interactions on different spatial scales.

  • Maintainer: Li-Ting Ku
  • License: GPL (>= 2)
  • Last published: 2025-05-12