Prioritization of Candidate Cancer Subtype Specific Drugs
Plot a global graph of the drug
Polt a subpathway network graph
Prioritization of candidate cancer subtype-specific drugs (PrioSubtype...
SubtypeDrug internal function
SubtypeDrug internal function
SubtypeDrug internal function
SubtypeDrug internal function
SubtypeDrug internal function
Get drug chemical structure diagram data
SubtypeDrug internal function
Plot a heat map of the normalized drug-disease reverse association sco...
Plot heat map of the drug regulated subpathway activity score
A systematic biology tool was developed to prioritize cancer subtype-specific drugs by integrating genetic perturbation, drug action, biological pathway, and cancer subtype. The capabilities of this tool include inferring patient-specific subpathway activity profiles in the context of gene expression profiles with subtype labels, calculating differentially expressed subpathways based on cultured human cells treated with drugs in the 'cMap' (connectivity map) database, prioritizing cancer subtype specific drugs according to drug-disease reverse association score based on subpathway, and visualization of results (Castelo (2013) <doi:10.1186/1471-2105-14-7>; Han et al (2019) <doi:10.1093/bioinformatics/btz894>; Lamb and Justin (2006) <doi:10.1126/science.1132939>). Please cite using <doi:10.1093/bioinformatics/btab011>.