Group Sequential Testing of a Treatment Effect Using a Surrogate Marker
Calculates the boundaries for the group sequential tests with futility...
Calculates the boundaries for the group sequential tests
Computes variances and standardized covariance matrix for the group se...
Tests for a treatment effect on the primary outcome using surrogate ma...
Computes group sequential boundaries with futility stopping
Computes group sequential boundaries
Computes kernel density estimate
Calculates kernel matrix
Compute the operating characteristics on the group sequential test wit...
Calculates the conditional mean function
Repeats a row.
Provides functions to implement group sequential procedures that allow for early stopping to declare efficacy using a surrogate marker and the possibility of futility stopping. More details are available in: Parast, L. and Bartroff, J (2024) <doi:10.1093/biomtc/ujae108>. A tutorial for this package can be found at <https://www.laylaparast.com/surrogateseq>. A Shiny App implementing the methods can be found at <https://parastlab.shinyapps.io/SurrogateSeqApp/>.