Target Equivalence Range Design
Descriptive Statistics
print.teqrDG
print.teqrOCact
print.teqrOCtox
teqrOCtox intermediate file that creates dose level data
teqrOCact intermediate file that creates dose level data
teqrOCact intermediate file that creates MTD/RP2D level data
teqrOCtox intermediate file that creates MTD level data
TEQR Design Dose Escalation/Expansion/De-escalation Guidelines
Activity Constrained for Toxicity (ACT) design trial simulator
TEQR Design trial simulator
The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.