Transmission Ratio Distortion
Find minor allele frequency (MAF) in case-trios, control-trios, or the...
Find transmission ratio of minor alleles in mother, father or both par...
Calculate genotype counts (additive model) for selected population.
Fit Loglinear model with and without adjustment for TRD.
Calculate theoretical prevalence of disease
Generate simulated popoulation of case- and control-trios
Count trios for each of the 15/16 strata with mother-father-child geno...
Compute TDT and adjusted TDT on case- and/or control-trios
Transmission Ratio Distortion
Transmission Ratio Distortion (TRD) is a genetic phenomenon where the two alleles from either parent are not transmitted to the offspring at the expected 1:1 ratio under Mendelian inheritance, leading to spurious signals in genetic association studies. Functions in this package are developed to account for this phenomenon using loglinear model and Transmission Disequilibrium Test (TDT). Some population information can also be calculated.