Clinical Trial Simulator
Define an Arm
Class of Arm
Triggering Condition by Calendar Time
Define a Controller
Class of Controller
Generate Correlated PFS and OS
Generate Correlated PFS, OS and Objective Response
An Action Function that Does Nothing
A wrapper of random number generator.
Define Endpoints
Class of Endpoint
Triggering Condition by Number of Randomized Patients
Triggering Condition by Number of Events or Non-missing Observations o...
Fit Cox Proportional Hazard Ratio model
Farrington-Manning test for rate difference
Fit linear regression model
Fit logistic regression model
Carry out log rank test
Get simulation output in the vignette adaptiveDesign.Rmd
Get simulation output in the vignette fixedDesign.Rmd
Class of GraphicalTesting
Class of GroupSequentialTest
Define a Listener
Class of Listener
Define a Milestone
Class of Milestones
Generate Time-to-Event Endpoint from Piecewise Constant Exponential Di...
Plot Triggering Time of Milestones in Simulated Trials
Plot result of three-state ill-death model
Generate Constant Variable
Solve Parameters in a Mixture Exponential Distribution
Solve Parameters in a Three-State Ill-Death Model
Generate Enrollment Time from Piecewise Constant Uniform Distribution
Summarize A Data Frame
Summary of Milestone Time from Simulated Trials
Define a Trial
Class of Trial
Calculate Parameters of Weibull Distribution as a Dropout Method
Simulate phase II and/or phase III clinical trials. It supports various types of endpoints and adaptive strategies. Tools for carrying out graphical testing procedure and combination test under group sequential design are also provided.
Useful links