TrialSize1.4.1 package

R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

AB.withDescalation

A + B Escalation Design with Dose De-escalation

AB.withoutDescalation

A + B Escalation Design without Dose De-escalation

ABE

Average Bioequivalence

ANOVA.Repeat.Measure

ANOVA with Repeat Measures

Carry.Over

Test the Carry-over effect

Cochran.Armitage.Trend

Cochran-Armitage's Test for Trend

Cox.Equality

Test for equality in Cox PH model.

Cox.Equivalence

Test for Equivalence in Cox PH model.

Cox.NIS

Test for non-inferiority/superiority in Cox PH model.

CrossOver.ISV.Equality

Test for Equality of Intra-Subject Variabilities in Crossover Design

CrossOver.ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities in Crossover Design

CrossOver.ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilitie in ...

Dose.Min.Effect

Williams' Test for Minimum effective dose (MED)

Dose.Response.binary

Linear Contrast Test for Binary Dose Response Study

Dose.Response.Linear

Linear Contrast Test for Dose Response Study

Dose.Response.time.to.event

Linear Contrast Test for Time-to-Event Endpoint in dose response study

gof.Pearson

Test Goodness of Fit by Pearson's Test

gof.Pearson.twoway

Test Goodness of Fit by Pearson's Test for two-way table

IBE

Individual Bioequivalence

InterSV.Equality

Test for Equality of Inter-Subject Variabilities

InterSV.NIS

Test for Equality of Inter-Subject Variabilities

ISCV.Equality

Test for Equality of Intra-Subject CVs

ISCV.Equivalence

Test for Equivalence of Intra-Subject CVs

ISCV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject CVs

ISV.Equality

Test for Equality of Intra-Subject Variabilities

ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities

ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilities

McNemar.Test

McNemar Test in 2 by 2 table

MeanWilliamsDesign.Equality

Test for Equality in Multiple-Sample William Design

MeanWilliamsDesign.Equivalence

Test for Equivalence in Multiple-Sample William Design

MeanWilliamsDesign.NIS

Test for Non-Inferiority/Superiority in Multiple-Sample William Design

Multiple.Testing

Multiple Testing procedures

Nonpara.Independ

Test for independence for nonparametric study

Nonpara.One.Sample

One Sample Location problem in Nonparametric

Nonpara.Two.Sample

Two sample location problem for Nonparametric

OneSampleMean.Equality

One Sample Mean Test for Equality

OneSampleMean.Equivalence

One Sample Mean Test for Equivalence

OneSampleMean.NIS

One Sample Mean Test for Non-Inferiority/Superiority

OneSampleProportion.Equality

One sample proportion test for equality

OneSampleProportion.Equivalence

One sample proportion test for equivalence

OneSampleProportion.NIS

One sample proportion test for Non-inferiority/Superiority

OneSide.fixEffect

One-Sided Tests with fixed effect sizes

OneSide.varyEffect

One-Sided Tests with varying effect sizes

OneWayANOVA.pairwise

Pairwise Comparison for Multiple-Sample One-Way ANOVA

OneWayANOVA.PairwiseComparison

One-way ANOVA pairwise comparison

PBE

Population Bioequivalence

Propensity.Score.nostrata

Propensity Score ignoring strata

Propensity.Score.strata

Propensity Score with Stratas

QOL

Quality of life

QT.crossover

Crossover Design in QT/QTc Studies without covariates

QT.parallel

Parallel Group Design in QT/QTc Studies without covariates

QT.PK.crossover

Crossover Design in QT/QTc Studies with PK response as covariate

QT.PK.parallel

Parallel Group Design in QT/QTc Studies with PK response as covariate

RelativeRisk.Equality

Relative Risk in Parallel Design test for Equality

RelativeRisk.Equivalence

Relative Risk in Parallel Design test for Equivalence

RelativeRisk.NIS

Relative Risk in Parallel Design test for Non-inferiority/Superiority

RelativeRiskCrossOver.Equality

Relative Risk in Crossover Design test for Equality

RelativeRiskCrossOver.Equivalence

Relative Risk in Crossover Design test for Equivalence

RelativeRiskCrossOver.NIS

Relative Risk in Crossover Design test for Non-inferiority/Superiority

Sensitivity.Index

Calculate the power for Sensitivity Index

Stuart.Maxwell.Test

Stuart-Maxwell Test

TrialSize-package

Sample Size calculation in Clinical Research

TwoSampleCrossOver.Equality

Two Sample Crossover Design Test for Equality

TwoSampleCrossOver.Equivalence

Two Sample Crossover Design Test for Equivalence

TwoSampleCrossOver.NIS

Two Sample Crossover Design Test for Non-Inferiority/Superiority

TwoSampleMean.Equality

Two Sample Mean Test for Equality

TwoSampleMean.Equivalence

Two Sample Mean Test for Equivalence

TwoSampleMean.NIS

Two Sample Mean Test for Non-Inferiority/Superiority

TwoSampleProportion.Equality

Two sample proportion test for equality

TwoSampleProportion.Equivalence

Two sample proportion test for equivalence

TwoSampleProportion.NIS

Two sample proportion test for Non-Inferiority/Superiority

TwoSampleSeqCrossOver.Equality

Two sample proportion Crossover design test for equality

TwoSampleSeqCrossOver.Equivalence

Two sample proportion Crossover design test for equivalence

TwoSampleSeqCrossOver.NIS

Two sample proportion Crossover design for Non-inferiority/Superiority

TwoSampleSurvival.Conditional

Test for two sample conditional data in exponential model for survival...

TwoSampleSurvival.Equality

Test for two sample equality in exponential model for survival data

TwoSampleSurvival.Equivalence

Test for two sample equivalence in exponential model for survival data

TwoSampleSurvival.NIS

Test for two sample Non-Inferiority/Superiority in exponential model f...

TwoSide.fixEffect

Two-Sided Tests with fixed effect sizes

TwoSide.varyEffect

Two-Sided Tests with varying effect sizes

Vaccine.CEM

Composite Efficacy Measure(CEM) for Vaccine clinical trials.

Vaccine.ELDI

The evaluation of vaccine efficacy with Extremely Low Disease Incidenc...

Vaccine.RDI

Reduction in Disease Incidence(RDI) for Vaccine clinical trials.

Vitro.BE

In Vitro Bioequivalence

WilliamsDesign.Equality

William Design test for equality

WilliamsDesign.Equivalence

Williams Design test for equivalence

WilliamsDesign.NIS

Williams Design test for Non-inferiority/Superiority

Functions and Examples in Sample Size Calculation in Clinical Research.

  • Maintainer: Vicky Qian Wu
  • License: GPL (>= 2.15.1)
  • Last published: 2024-11-05