Implementing EFF-TOX and Monotone Utility Based Phase 12 Trials
Returns the desireability value of a dose.
Gives the dose to assign the next patient cohort using monotone utilit...
Returns prior dose-specific means.
Simulates replications from EFF-TOX phase 12 trial.
Simulates replications from the monotone utility based phase 12 trial.
Samples from the posterior of the utility based phase12 model.
Contains functions for simulating phase 12 trial designs described by Chapple and Thall (2019) including simulation and the EFF-TOX trial and simulation and implementation of the U12 trial. Functions for implementing the EFF-TOX trial are found in the package 'Phase123'.