Design and Analysis of Locally or Globally Efficient Adaptive Designs
Analyze data according to a globally efficient adaptive design.
Analyze data according to a locally efficient adaptive design.
adpss: A package for design and analysis of a locally or globally effi...
Calculate expected sample size for a globally efficient adaptive desig...
Calculate sample size or power for a globally efficient adaptive desig...
Calculate sample size or power for a locally efficient adaptive design...
Construct a working test and implement an interim or the final analysi...
Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.