mimwrap function

Wrapper function for mutual information matrix estimators

Mutual information matrix estimation wrapper function for various mutual information estimators. Depends on infotheo package for mutual information estimators on discrete variables.

mimwrap(dataset, estimator="pearson", disc="equalwidth", bins = sqrt(ncol(dataset)))

Arguments

• dataset: Data gene expression matrix where rows denote genes (features) and columns samples.

• estimator: estimators for continuous variables "pearson" (default), "spearman", "kendall", "spearman"

  estimators for discrete variables (infotheo package) "emp", "mm","sg","shrink"

• disc: only required for discrete estimators (see infotheo package) "equalwidth" (default), "globalequalwidth" , "equalfreq"

• bins: number of bins for the descretize function (infotheo), default sqrt(ncol(dataset))

Returns

mimwrap returns a symmetric mutual information matrix for various mutual information estimators.

Details

A mutual information matrix is estimated from a gene expression data set

References

Patrick E Meyer, Frederic Lafitte and Gianluca Bontempi, minet: A R/Bioconductor Package for Inferring Large Transcriptional Networks Using Mutual Information, BMC Bioinformatics 2008, 9:461

Carsten O. Daub, Ralf Steuer, Joachim Selbig, and Sebastian Kloska, Estimating mutual information using B-spline functions - an improved similarity measure for analysing gene expression data, BMC Bioinformatics. 2004; 5: 118

de Matos Simoes R, Emmert-Streib F., Bagging statistical network inference from large-scale gene expression data., PLoS One. 2012;7(3):e33624. Epub 2012 Mar 30.

Examples

data(expmat)
mim <- mimwrap(expmat)