Conduct Simulation Study of Bayesian Optimal Interval Design with BOIN-ET Family
BOIN-ET: Bayesian Optimal Interval Design for Dose-Finding Based on Ef...
Create Report-Ready Tables from BOIN-ET Results
Create GT Table for Design Parameters
Create GT Table for Operating Characteristics
Extract Tidy Data from BOIN-ET Results
Extract Design Parameters Summary
Extract Operating Characteristics in Tidy Format
Format BOIN-ET Results for Reporting
Fractional Polynomial Logistic Regression for Dose-Efficacy Modeling
gBOIN-ET: Generalized Bayesian Optimal Interval Design for Ordinal Gra...
Grid Search Optimization for BOIN-ET Design Boundaries
Launch the Shiny App
Model Averaging of Multiple Unimodal Isotonic Regression
Optimal Biological Dose Selection
Print boinet
Print gboinet
Print tite.boinet
Print tite.gboinet
Summary method for boinet objects
Summary method for gboinet objects
Summary method for tite.boinet objects
Summary method for tite.gboinet objects
TITE-BOIN-ET: Time-to-Event Bayesian Optimal Interval Design
TITE-gBOIN-ET: Time-to-Event Generalized BOIN Design for Ordinal Grade...
Discrete Scoring Utility Function for Toxicity-Efficacy Trade-offs
Truncated Linear Utility Function for Toxicity-Efficacy Trade-offs
Weighted Utility Function for Toxicity-Efficacy Trade-off
Bayesian optimal interval based on both efficacy and toxicity outcomes (BOIN-ET) design is a model-assisted oncology phase I/II trial design, aiming to establish an optimal biological dose accounting for efficacy and toxicity in the framework of dose-finding. Some extensions of BOIN-ET design are also available to allow for time-to-event efficacy and toxicity outcomes based on cumulative and pending data (time-to-event BOIN-ET: TITE-BOIN-ET), ordinal graded efficacy and toxicity outcomes (generalized BOIN-ET: gBOIN-ET), and their combination (TITE-gBOIN-ET). 'boinet' is a package to implement the BOIN-ET design family and supports the conduct of simulation studies to assess operating characteristics of BOIN-ET, TITE-BOIN-ET, gBOIN-ET, and TITE-gBOIN-ET, where users can choose design parameters in flexible and straightforward ways depending on their own application.