simul_pfs function

Simulation of Progression Free Survival Times

simul_pfs(
  lp_aft,
  sigma_aft,
  recr_duration,
  rate_cens,
  n_events,
  add_uncensored_pfs = FALSE
)

Arguments

• lp_aft: (numeric)

  linear predictor values for the accelerate failure time model (AFT).

• sigma_aft: (number)

  standard deviation for the AFT model.

• recr_duration: (number)

  duration of recruitment.

• rate_cens: (number)

  rate for the exponentially distributed censoring process.

• n_events: (count)

  number of events to reach for the study end.

• add_uncensored_pfs: (flag)

  whether to add the uncensored PFS as well to the resulting data.frame.

Returns

A data.frame with columns tt_pfs (PFS time) and ev_pfs (corresponding event indicator with 1 for an event and 0 for censored), and optionally tt_pfs_uncens.

Examples

set.seed(123)
simul_pfs(
  lp_aft = rnorm(100),
  sigma_aft = 1,
  recr_duration = 0.2,
  rate_cens = 2,
  n_events = 20
)