Clinical Pharmacokinetics Toolkit
Convert quantity expressed relative to BSA to absolute units
Convert quantity expressed in absolute units relative to normalized BS...
Calculate accumulation ratio This is the ratio of drug concentration o...
Add residual variability to data
factors or characters to numeric
Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)
Calculate adjusted body weight (ABW)
Calculate AKI stage
Remove less-than/greater-than symbols and convert to numeric
Calculate the amounts in all compartments in a compartmental PK system...
Calculate baseline sCr
Calculate BMI
Calculate body surface area
Calculate half-life based on two points
Checks whether required covariates for eGFR calculations are present
clinPK
Convert cm to inch
Convert concentration to molar
Calvert equation for carboplatin
Estimate serum creatinine
Estimate serum creatinine in neonates
Calculate commonly used "dosing weight"
Calculate eGFR
Calculate eGFR based on Cystatin C measurements
Calculate fat-free mass
Concentration predictions for 1-compartmental oral PK model after sing...
Calculate terminal half-life for 1-compartment model
Concentration predictions for 2-compartmental PK model, single or mult...
Cmax for 2-compartmental PK model, bolus dosing at steady state
Cmin (trough) for 2-compartmental PK model, bolus dosing at steady sta...
Calculate dose to achieve steady state Cmax for 2-compartmental PK mod...
Calculate dose to achieve steady state trough for 2-compartmental PK m...
Concentration predictions for 2-compartmental PK model, bolus dosing a...
Concentration predictions for 2-compartmental PK model, single or mult...
Cmax (trough) for 2-compartmental PK model, bolus dosing at steady sta...
Cmin (trough) for 2-compartmental PK model, bolus dosing at steady sta...
Calculate dose to achieve steady state Cmax for 2-compartmental PK mod...
Calculate dose to achieve steady state trough for 2-compartmental PK m...
Concentration predictions for 2-compartmental PK model with infusion d...
Calculate half-life(s) for 2-compartment model
Calculate average half-life for 2-compartment model during a specific ...
Print function for output from nca()
Read WHO growth tables
Time to steady state In either time units or number of doses
Valid units
Convert any weight unit to kg
Convert albumin from / to units
Convert bilirubin from / to units
Convert concentration units
Convert serum creatinine from various assays to Jaffe
Convert creatinine to different unit
Convert flow (e.g. clearance) from / to units
Convert dose to expected AUCinf or AUCt for 1 compartment linear PK mo...
Returns parameters needed to calculate eGFR according to the method sp...
Helper function to grab the conversion factor from an input unit and g...
Generic function to calculate the dose nearest to a specific dose unit...
Generic function to calculate the interval nearest to a possible dosin...
Calculate fraction of steady state at particular time after start of d...
Greater-than-or-equal-to with a little room for floating point precisi...
Less-than-or-equal-to with a little room for floating point precision ...
Convert inch to cm
Check if values in vector are empty
Calculate AKI stage according to KDIGO criteria
Convert kg to lbs
Convert kg to oz
Convert lbs to kg
Calculate mean between two values in a vector Used in NCA for calculat...
Convert molar to concentration
Cmax for linear 1-compartment PK model at steady state, bolus dosing
Cmin (trough) for linear 1-compartment PK model at steady state, bolus...
Calculate dose to achieve steady state Cmax for 1-compartmental PK mod...
Calculate dose to achieve steady state trough for 1-compartmental PK m...
Concentration predictions for 1-compartmental PK model with bolus dosi...
Concentration predictions for 1-compartmental PK model after single or...
Cmax for linear 1-compartment PK model at steady state
Cmin (trough) for linear 1-compartment PK model at steady state
Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-comp...
Calculate dose to achieve steady state Cmax for 1-compartmental PK mod...
Calculate dose to achieve steady state trough for 1-compartmental PK m...
Concentration predictions for 2-compartmental PK model with infusion d...
Calculate ideal body weight in kg for children and adults
Calculate elimination rate when given two TDM samples
Calculate elimination rate when given a single TDM sample
Calculate kinetic GFR
Calculate lean body weight
Calculate neutropenia grade from ANC
Perform an NCA based on a NONMEM-style dataset
NCA core function to perform linear trapezoid calculations for post-in...
NCA core function to perform log-linear trapezoid calculations for pos...
Convert oz to kg
Percentile BMI for age for children
Percentile height or weight for age for children
Percentile height for age for children
Percentile weight for age for children
Concentration predictions for 1-compartmental PK model after single or...
Provides equations commonly used in clinical pharmacokinetics and clinical pharmacology, such as equations for dose individualization, compartmental pharmacokinetics, drug exposure, anthropomorphic calculations, clinical chemistry, and conversion of common clinical parameters. Where possible and relevant, it provides multiple published and peer-reviewed equations within the respective R function.