Implement Covariate-Adaptive Randomization
Big Stick Design
Simulations of the Big Stick Design
Covariate-Adjusted Biased Coin Design
Simulations of the Covariate-Adjusted Biased Coin Design
Internal covadap Functions
covadap: Implements Covariate-Adaptive Randomization procedures
-optimum biased coin design
Simulations of the -optimum biased coin design
Efficient Covariate-Adaptive Design
Simulations of the Efficient Covariate-Adaptive Design
Covariate-Adaptive randomization by Hu and Hu
Simulations of the Covariate-Adaptive randomization by Hu and Hu
Covariate-Adaptive randomization by Ma and Hu
Simulations of the Covariate-Adaptive randomization by Ma and Hu
Pocock and Simon's minimization method
Simulations of the Pocock and Simon's minimization method
Summary of Covariate-Adaptive Designs
Implementing seven Covariate-Adaptive Randomization to assign patients to two treatments. Three of these procedures can also accommodate quantitative and mixed covariates. Given a set of covariates, the user can generate a single sequence of allocations or replicate the design multiple times by simulating the patients' covariate profiles. At the end, an extensive assessment of the performance of the randomization procedures is provided, calculating several imbalance measures. See Baldi Antognini A, Frieri R, Zagoraiou M and Novelli M (2022) <doi:10.1007/s00362-022-01381-1> for details.