isobole function

Creating isobolograms

'isobole' displays isobole based on EC/ED50 estimates from a log-logistic model. Additionally isoboles determined by the concentration addition model, Hewlett's model and Voelund's model can be added to the plot.

isobole(object1, object2, exchange = 1, cifactor = 2, ename = "e", 
xaxis = "100", xlab, ylab, xlim, ylim, ...)

Arguments

• object1: object of class 'drc' where EC/ED50 parameters vary freely.
• object2: object of class 'drc' where EC/ED50 parameters vary according to Hewlett's model.
• ename: character string. The name of the EC/ED50 variable.
• xaxis: character string. Is the mixture "0:100" or "100:0" on the x axis?
• exchange: numeric. The exchange rate between the two substances.
• cifactor: numeric. The factor to be used in the confidence intervals. Default is 2, but 1 has been used in publications.
• xlab: an optional label for the x axis.
• ylab: an optional label for the y axis.
• xlim: a numeric vector of length two, containing the lower and upper limit for the x axis.
• ylim: a numeric vector of length two, containing the lower and upper limit for the y axis.
• ...: Additional graphical parameters.

Details

The model fits to be supplied as first and optionally second argument are obtained using mixture and drm.

Returns

No value is returned. Only used for the side effect: the isobologram shown.

References

Ritz, C. and Streibig, J. C. (2014) From additivity to synergism - A modelling perspective Synergy, 1 , 22--29.

Author(s)

Christian Ritz

See Also

The examples in acidiq, glymet and mecter.