Dose Transition Pathways for Continual Reassessment Method
Execute the CRM
Simulate CRM trials using specified design options
Execute the TITE-CRM
Simulate TITE-CRM trials using specified design options
Simulate TITE-CRM trials using specified design options
Produce the Dose Transition Pathways
Produce DTP flow diagram
Plot of posterior estimates from the CRM
Stopping for consensus
Stopping for excess toxicity - Empiric method
Stopping for excess toxicity - Logistic method
Stopping for sample size reached
Provide a summary of applied_crm output
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.