Adaptive Enrichment Designs with Sample Size Re-Estimation
Calculate the critical value used at the final analysis in AED
Conduct the simulation studies of the Adaptive Enrichment Design witho...
Calculate the critical value used at the final analysis of the Adaptiv...
Calculate the conditional power of the Adaptive Enrichment Design with...
Calculate the sample size required at the second stage of the adaptive...
Conduct the simulation studies of the Adaptive Enrichment Design (Stra...
Calculate the futility and efficacy stopping boundaries of the Adaptiv...
Calculate the and the critical value in the Adaptive Enrichme...
Conduct the simulation studies of the Adaptive Enrichment Design (Stra...
Calculate the futility and efficacy stopping boundaries in Adaptive en...
Calculate the and the critical value in the Adaptive Enrichme...
Conduct the simulation studies of the Adaptive Enrichment Design (Stra...
Conduct the simulation studies of the Marker Sequential Test design
Conduct the simulation studies of the standard design
Commonly used -spending functions
Sample size calculation for the standard design with continuous endpoi...
Calculate the futility and efficacy stopping boundaries for Sample Siz...
Calculate the and the critical value in Sample Size Re-estima...
Conduct the simulation studies using SSR
Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi: 10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.