grantham0.1.4 package

Calculate the Grantham Distance

amino_acid_pairs

Generate amino acid pairs

amino_acids

The 20 standard amino acids

as_one_letter

Convert three-letter amino acid codes to one-letter codes

as_three_letter

Convert one-letter amino acid codes to three-letter codes

grantham_distance_exact

Grantham's distance (exact)

grantham_distance_original

Grantham's distance (original)

grantham_distance

Grantham distance

grantham_equation

Grantham distance

grantham-package

grantham: Calculate the Grantham Distance

ij2k

Convert an (i, j) index to a linear index.

Download source packageRead PDF manual

A minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

  • Maintainer: Ramiro Magno
  • License: MIT + file LICENSE
  • Last published: 2025-05-31

Useful links