hbim-package

Hill/Bliss Independence Model for Multicomponent Vaccines

Calculate expected relative risk and proportion protected assuming normally distributed log10 transformed antibody dose for several component vaccine. Uses Hill models for each component which are combined under Bliss independence. (see Saul and Fay (2007) doi:10.1371/jounal.pone.0000850). package

Details

The hbim package allows users to reproduce plots and calculations for Saul and Fay (2007). See vignette("hbimdetails").

Author(s)

M.P. Fay, Maintainer: Michael Fay mfay@niaid.nih.gov

References

Saul A, Fay MP (2007). Human Immunity and the Design of Multi-Component, Single Target Vaccines. PLoS ONE 2(9): e850. doi:10.1371/jounal.pone.0000850