Generate Concentration-Time Profiles from Linear PK Systems
Coerce a pkprofile to a data.frame
Construct a block-diagonal matrix.
Convert from standard deviation and correlation matrix to covariance m...
Get the doses from a PK profile.
Get the final state or time of a PK profile.
Generate individual random effects from a multivariate normal distribu...
Half-lives of a linear PK system.
Runs the interactive shiny app.
Construct a symmetric matrix from its lower triangle.
Printing and plotting methods for class pkprofile.
Continue an existing concentration-time profile.
Generate a concentration-time profile.
Derive secondary PK parameters.
Generate concentration-time profiles from linear pharmacokinetic (PK) systems, possibly with first-order absorption or zero-order infusion, possibly with one or more peripheral compartments, and possibly under steady-state conditions. Single or multiple doses may be specified. Secondary (derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half-life, etc.) are computed.