Mander and Thompson Designs
Augment a grid of candidate designs with type 1 and type 2 error proba...
Create a grid of candidate designs
Finds optimal and minimax designs for either Simon's 2-stage or Mander...
Pipe operator
Plot the power curve(s) for the given design(s)
Obtain default bounds for the construction of the search grid.
Implements Mander & Thompson's (2010) <doi:10.1016/j.cct.2010.07.008> methods for two-stage designs optimal under the alternative hypothesis for phase II [cancer] trials. Also provides an implementation of Simon's (1989) <doi:10.1016/0197-2456(89)90015-9> original methodology and allows exploration of the operating characteristics of sub-optimal designs.