NCA Calculations and Population Model Diagnosis
Calculates a set of statistics for a given array of numbers.
Plots drug plasma concentration vs time data
Estimate individual NCA metrics.
Plots histogram of selected set of NCA metrics.
Plots population histogram of the NCA metrics selected for model diagn...
Prepare individual PK data
Check observed data
Check simulated data
Plot individual deviation of NCA metrics estimated from observed and s...
Prepare individual PK data
Plots population histogram of the NCA metrics selected for model diagn...
Calculates individual normalized prediction distribution errors (NPDE)...
Calculates individual prediction distribution errors (PDE) and scaled ...
Check observed data
Performs NCA calculations and population PK model diagnosis.
output value with correct digits and trailing zero
Read NONMEM table files produced.
A flexible tool that can perform (i) traditional non-compartmental analysis (NCA) and (ii) Simulation-based posterior predictive checks for population pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics. The methods are described in Acharya et al. (2016) <doi:10.1016/j.cmpb.2016.01.013>.
Useful links