phenoModel function

Model function for the Phenobarb data

A model function for a model used with the Phenobarb data. This function uses compiled C code to improve execution speed.

phenoModel(Subject, time, dose, lCl, lV)

Arguments

• Subject: an integer vector of subject identifiers. These should be sorted in increasing order.
• time: numeric. A vector of the times at which the sample was drawn or the drug administered (hr).
• dose: numeric. A vector of doses of drug administered ($\mu$g/kg).
• lCl: numeric. A vector of values of the natural log of the clearance parameter according to Subject and time.
• lV: numeric. A vector of values of the natural log of the effective volume of distribution according to Subject and time.

Details

See the details section of Phenobarb for a description of the model function that phenoModel evaluates.

Returns

a numeric vector of predicted phenobarbital concentrations.

References

Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer. (section 6.4)

Author(s)

José Pinheiro and Douglas Bates bates@stat.wisc.edu